Brittney Newby


Advanced Concentration

Immunology & Microbiology

Mentor

Clayton E. Mathews, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled 

August 2013 - MD-PHD

Lab Room

Biomedical Sciences Building , J527 

Lab Phone

352-272-9301 

E-mail

brittney.newby@ufl.edu 

Education 

B.S.,  Chemistry, Florida A&M University, 2009

Dissertation Research

Title: Type 1 IFN in Type 1 Diabetes: Influencing Beta-Cell and CD8+ T cell interactions. 
Objective: Type 1 Interferons (T1-IFN) are consistently found within the pancreata of patients with Type 1 Diabetes. However, there is a paucity of literature that seeks to understand what role these cytokines play in altering the diabetic microenvironment in T1D islets. The objective of my research is to test the hypothesis that Type 1 Interferons (T1-IFN) alter the microenvironment of the diabetic islet through regulation of members of the MHC Class I antigen processing and presentation pathway in beta cells and by directly enhancing cytotoxic lymphocyte-mediated beta cell death.

Publications

1.    Adams A, McBratney-Owen B, Newby B, Bowen ME, Olsen BR, Warman ML. (2013) Presphenoidal synchondrosis fusion in DBA/2J mice. Mamm Genome. 24(1-2):54-62. [PMCID: PMC3560942] 

2.    Hann, S., Kvenvold, L., Newby, B. N., Hong, M. & Warman, M. L. (2013) A Wisp3 Cre- knockin Allele Produces Efficient Recombination in Spermatocytes during Early Prophase of Meiosis I. PLoS ONE 8, e75116. [PMCID: PMC3769254] [PMID: 24040393] 

3.    Newby BN, Terada N, Mathews CE. In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy. 2014 Aug;25(8):378-80. [PMID: 24958526] 

4.     Liu C, Xu Y, Newby BN, Chen J, Reeves WH & Mathews CE. NADPH oxidase derived Reactive Oxygen Species Promote CD8+ T cell Effector Functions in Type 1 Diabetes. - Submitted

Abstracts Presented at Meetings

1.    Newby B.N., Lightfoot Y.L., Chen J, Brusko T.M., Mathews C.E. The T1D-Associated Protective Allotype of MT-ND2 Inhibits the Cytotoxic Activity of Beta Cell Directed T Cells. American Diabetes Association (ADA) 75th Scientific Sessions. June 5 9, 2015. Boston, MA.  

2.    Armitage, L. and Newby B.N., Santostefano, K., Chen, J., Terada, N., Savinov, A., Brusko, T.M., Mathews, C.E., Wallet, M.A. Isogenic system to discriminate cell type specific effects of individual T1D risk alleles. 2015 Human Islet Research Network (HIRN) Meeting. May 13-15, 2015. Bethesda, MD.
3.    Newby B., Lightfoot Y., Thompson J., Clare-Salzler M., Brusko T.M., Mathews C. Type 1 Interferons Prime Human β Cells for Destruction by Autoreactive Human Cytotoxic T Lymphocytes. American Diabetes Association (ADA) 73rd Scientific Sessions. June 21 25, 2013. Chicago, IL.

Honors & Awards

1.    Grinter Fellowship, 2013
2.    UF MD-PhD Travel Award, 2015
3.    UF COM Medical Guild Advancement to Candidacy Award, 2015
4.    F30 Ruth L. Kirschstein NRSA Individual MD-PhD Pre-doctoral Fellowship, May 2015 May 2020

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last revised 9/17/13 tr