Satya Narayan, Ph.D.
Involvement of adenomatous polyposis coli (APC) in colorectal and breast carcinogenesis
My long-term goal is establish the role of adenomatous polyposis coli (APC) in the initiation and transformation of epithelial cells after exposure with carcinogenic agents. Our recent studies suggest that the APC protein can modulate base excision repair (BER) pathway through an interaction with DNA polymerase b (Pol-b) and flap endonuclease 1 (Fen-1). Taken together with our finding that the transcription of APC is enhanced by alkylating agents, our results suggest that APC modulation of BER activity may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. Our findings provide evidence supporting this novel concept and suggest that these results have implications for the development of more effective strategies for chemoprevention, prognosis, and chemotherapy of colorectal and breast tumors. Currently, the main research focus in our lab is on the following three projects: 1) Role of APC in BER and colorectal carcinogenesis, 2) Role of APC in BER and cigarette smoke carcinogen-induced breast carcinogenesis, and 3) Chemotherapeutic intervention of colorectal and breast carcinogenesis.
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office: CGRC Room 255
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Satya Narayan received his Ph.D. from Panjab University, Chandigarh, India in 1987. He received his postdoctoral training under the tutelage of Gary W. Winston, Ph.D. (Department of Biochemistry, Louisiana Sate University, Baton Rouge, LA) and Pomila Singh, Ph.D. (Department of Surgery, University of Texas Medical branch (UTMB), Galveston, TX) in the field of alcohol-induced drug metabolic system (1987-1989) and hormonal regulation of colon cancer development (1989-1991), respectively. He further received his training in the field of transcriptional regulation of genes and DNA repair mechanisms under the able guidance of Samuel H. Wilson, MD, while working as a Scientist at the Sealy Center for Molecular Science, UTMB (1991-1996). In 1996, he became an Assistant Professor in the Department of Human Biological Chemistry and Genetics, UTMB. In 2000, he joined University of Florida as an Assistant Professor in the Department of Anatomy and Cell Biology and UF Shands Cancer Center.
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