Michael S. Kilberg, Ph.D.
Regulation of chromatin structure and transcription by nutrients
Nutrient control of mammalian gene expression is a poorly understood process that is important to general cellular nutrition, as well as to the progression and treatment of numerous diseases. Our program is focused on the changes in chromatin structure, epigenetics, and transcriptional control of several human genes, including transcription factor s themselves, following protein or amino acid deprivation. For a number of genes we have characterized genomic sequences that comprise an Amino Acid Response Element (AARE) that mediate the regulated response of this class of genes to amino acid limitation. Both standard and innovative biochemical and molecular biological approaches have been used to characterize these nutrient-responsive cis-acting elements and to document that mammalian cells exhibit is a self-limiting program of transcriptional activation following amino acid limitation. The bZIP transcription factors ATF4, ATF3, and C/EBPb bind to the AARE in a specific temporal sequence to regulate transcription. These studies will generate valuable new information regarding the mechanisms by which mammalian cells respond to fluctuations in nutrient availability.
Not Accepting New Students This Year
Professor Michael S. Kilberg earned his Ph.D. degree in biochemistry and molecular biology from the University of South Dakota for his work on the effect of ionizing radiation and diabetes on hepatic amino acid transport and metabolism. In 1977, he joined Hal Christensen's laboratory in the Department of Biological Chemistry at the University of Michigan where he studied the regulation of amino acid transport. Dr. Kilberg joined the faculty at the University of Florida in 1980. He has organized several international symposia and has written multiple chapters for both the Annual Review of Nutrition and the Annual Review of Biochemistry. Dr. Kilberg has served three terms on the Editorial Board of the Journal of Biological Chemistry. He was awarded the College of Medicine Faculty Research Award in 1992, the University of Florida Research Foundation Professorship in 1997, the Professorial Excellence Program Award in 1998, and the University of Florida Doctoral Mentoring Award in 2006.
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