Jeannine Brady, Ph.D.
Protein translocation, structure/function and immunogenicity in pathogenic streptococci
Dr. Brady has studied and published in the fields of protein structure-function and host pathogen interactions and her laboratory encompasses several broad areas of research. Her group was the first to demonstrate the dispensability of the signal recognition particle co-translational protein translocation pathway in any living cell and to identify the presence of a second member of the Oxa/YidC/Alb family of membrane-localized chaperones in the streptococci. Current work is focused on understanding unique features of membrane biogenesis and protein secretion in this genus. In addition, work is ongoing to understand the molecular basis of bacterial adhesion and biofilm formation, particularly with regard to the oral pathogen Streptococcus mutans Dr. Brady is also particularly interested in mechanisms of protective immunity and has demonstrated the feasibility of utilizing monoclonal antibodies to redirect host responses towards increased efficacy. Ongoing work is directed at elucidating the molecular mechanisms of antibody-mediated immunomodulation and to use monoclonal antibodies as tools to probe structural features of antigens with the goal of guided re-engineering and improvement in vaccine design.
Possibly Accepting New Students This Year
lab: D4-21,23, 24
Dr. Brady grew up in Trenton, New Jersey and received her B.S. degree in Microbiology from Rutgers University in 1976. She worked for several years doing diagnostic virology and subsequently in clinical research in the pharmaceutical industry. She returned to graduate school and completed her Ph.D. in 1989 in the Department of Immunology and Medical Microbiology at the University of Florida. She went on to a post-doctoral position in the UF College of Dentistry Department of Oral Biology where she has remained and currently serves as an Associate Professor.
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