Hideko Kasahara, M.D., Ph.D.
Our current research interest is to understand the function of Nkx2.5; an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes. Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals are used for human Nkx2.5) have emerged as a fascinating story both because of the roles this transcription factor plays in formation of the developing heart, as well as in maintenance of the normal heart after birth and through to adulthood. We are particularly interested in a cardiac disorder in adults: progressive AV block and left ventricular dysfunction caused by NKX2.5 mutations. However, the current understanding of the NKX2.5 function is very limited in explaining the molecular mechanisms explaining why the molecular mechanisms of mutations of NKX2.5 cause congenital heart disease.
Accepting New Students This Year
office: Medical Sciences, M540
lab: Medical Sciences, M538, M540, M541
phone: (352) 846-1503
1985: M.D. Nagoya University Medical School, Japan (Medicine)
1994: Ph.D. Nagoya University Medical School, Japan (Cardiology, Cell Biology)
1991-1994: National Institute for Physiological Sciences, Japan (Cell Biology)
1994-1997: Postdoctoral Fellow, University of Michigan, Ann Arbor, MI
1997-1998: Postdoctoral Fellow, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA
1998-2001: Instructor of Medicine, Harvard Medical School / Beth Israel Deaconess Medical Center
2002- Assistant Professor in the Department of Physiology and Functional Genomics, University of Florida College of Medicine
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