Charles A. Wingo, M.D.
Over the past 25 years, my research interest has included disorders of fluid and electrolyte balance, acid-base balance and hypertension. 1) My laboratory discovered that aldosterone stimulates and represents a number of novel genes in the kidney, including prepro endothelin-1. We are currently actively studying the role of endothelin as a regulator of aldosterone action. 2) We have demonstrated that the kidney expresses two H,K-ATPases which are involved in acid-base and potassium balance. Our studies with genetically altered mice with disruption of theses genes show that both contribute to normal renal acid secretion. In the stomach and the kidney a K channel is necessary to recycle K for the function of H,K-ATPase. The molecular nature of this K channel is the subject of active investigation. Our most recent observations have identified that the major gene responsible for congenital long QT syndrome (KvLQT), also known as KCNQ1, is expressed in the kidney. Inhibition or disruption of this K channel inhibits gastric acid secretion, prolongs the cardiac QT interval, and impairs hearing.
Possibly Accepting New Students This Year
office: VA E580A
lab: VA E521 and E566
Dr. Wingo received his M.D. degree in 1975 from the Louisiana State University School of Medicine in New Orleans. After completion of his internal medicine training at the University of Texas Medical School at Houston, he pursued his fellowship training in nephrology at the University of Texas Southwestern Medical School under the direction of Drs. Harry R. Jacobson, Juha P. Kokko, and Donald W. Seldin from 1978 through 1981. Dr. Wingo joined the faculty at the University of Florida in 1981. He is recognized nationally and internationally for his research in renal physiology, and potassium and acid-base transport. He received a Veterans Affairs Career Development Award in 1985 and is a past-president of the Southern Society for Clinical Investigation.
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